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Grant Title: Role of Tunneling Nanotubes in Promoting Chemotherapy Resistance of Pancreatic Cancer

Grant Year: 2013

Recipient: Emil Lou, MD, PhD, FACP
Assistant Professor of Medicine
University of Minnesota
Division of Hematology, Oncology and Transplantation

“My team and I are very grateful for support afforded by the NPF grant. This funding allowed us freedom to pursue an innovative and high-risk angle of our work that we believe will yield new insights into pancreatic cancer cell communication and mechanisms of drug resistance. It has also allowed me to apply for larger-scale research grants using the NPF grant results as preliminary data.”

Publications stemmed from The NPF Research Grant:

Desir, Snider, O’Hare, Patrick et al. Scientific Reports (2018) 8:9484 Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer
To read full publication, please CLICK HERE.

Thayanithy et al. Cell Communication and Signaling (2017) 15:46. A transwell assay that excludes exosomes for assessment of tunneling nanotube mediated intercellular communication.
DOI 10.1186/s12964-017-0201-2
To read full publication, please CLICK HERE.

Lou, E., O’Hare, P., Subramanian, S., Steer, C. Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments. The FEBS Journal. (2016) 1-9.
To read full publication, please CLICK HERE.

Lou et al – Pancreatic cancer: modulation of KRAS, MicroRNAs, and intercellular communication in the setting of tumor heterogeneity. Pancreas. 2013 Nov;42(8):1218-26.
To read full publication, please CLICK HERE.